منابع مشابه
α-Allyl-α-aryl α-Amino Esters in the Asymmetric Synthesis of Acyclic and Cyclic Amino Acid Derivatives by Alkene Metathesis
Allylating agents were explored for the asymmetric synthesis of α-allyl-α-aryl α-amino acids by tandem N-alkylation/π-allylation. Cross-metathesis of the tandem product was developed to provide allylic diversity not afforded in the parent reaction; the synthesis of homotyrosine and homoglutamate analogues was completed. Cyclic α-amino acid derivatives could be accessed by ring-closing metathesi...
متن کاملSynthesis of chiral N-phosphinyl α-imino esters and their application in asymmetric synthesis of α-amino esters by reduction
A variety of chiral N-phosphinyl α-imino esters have been synthesized for the first time from ketoesters and phosphinylamide, which were then reduced by L-selectride to give the corresponding N-phosphinyl-protected α-amino esters. The reduction proceeded very well with excellent chemical yields (88-98%) as well as high diastereoselectivities (96:4 to 99:1). Some of these products could be obtai...
متن کاملHydrothermal Syntheses of Amino Acid- Montmorillonites and Ammonium-micas
-An attempt has been made to synthesize nitrogenous clay minerals hydrothermally from silicaalumina gels in the presence of amino acids, namely glycine and lysine, The products have been characterized by X-ray powder diffraction, by analyses for C and N contents, and by their infrared spectra. Amino acid-montmorillonites have been prepared under hydrothermal conditions of 200-250~ and 1000 atm....
متن کاملAsymmetric Michael addition of α-fluoro-α-nitro esters to nitroolefins: towards synthesis of α-fluoro-α-substituted amino acids.
α-Fluoro-α-nitro esters were used as reaction partners in Michael addition to nitroalkenes, and the products were obtained in excellent chemical yields and with high enantioselectivities. Moreover, α-fluoro-α-amino ester with a quaternary α-carbon was prepared for the first time.
متن کاملAutocatalytic one pot orchestration for the synthesis of α-arylated, α-amino esters.
A novel acetyl chloride-mediated cascade transformation involving three components (benzyl carbamate, ethyl glyoxylate and arene nucleophiles) is reported. Aryl orthogonally protected α-amino acids are obtained in a one pot cascade, using a mild AcOH-AcCl system, via a critical autocatalytic dehydration-activation step ensuring an original and efficient Friedel-Crafts orchestration.
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ژورنال
عنوان ژورنال: Bulletin of the Chemical Society of Japan
سال: 1964
ISSN: 0009-2673,1348-0634
DOI: 10.1246/bcsj.37.191